Major recommendations
- Pneumococcal vaccine–naive adults aged 65 years or older (or adults ≥65 years whose pneumococcal vaccine history is unknown) should receive 1 dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by a dose of 23-valent pneumococcal polysaccharide vaccine (PPSV23) 6 to 12 months later (minimum duration between PCV13 and PPSV23, 8 weeks).
- Adults aged 65 years or older who have previously received 1 or more doses of PPSV23 should receive 1 dose of PCV13 1 year or longer after the most recent PPSV23 dose.
- In adults who received PPSV23 before age 65 years, PCV13 should be given after age 65 years (and ≥1 year after the PPSV23 was given). PPSV23 should then be repeated 6 to 12 months later (and ≥5 years since the initial PPSV23 injection).
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