¿ Cuándo prescribir azitromicina ?

http://www.australianprescriber.com/magazine/38/3/87/9

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and excellent tissue penetration.

It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used in preference to other macrolides for some sexually transmitted and enteric infections.

Azithromycin has additional immunomodulatory effects and has been used in chronic respiratory inflammatory diseases for this purpose.

Potential major adverse effects include cardiovascular arrhythmias and hearing loss. Macrolide resistance is also a problem, as are interactions with commonly prescribed drugs.

Azitromicina en infecciones respiratorias de vías bajas: una revisión Cochrane

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001954.pub4/abstract

Authors' conclusions

There is unclear evidence that azithromycin is superior to amoxycillin or amoxyclav in treating acute LRTI. In patients with acute bronchitis of a suspected bacterial cause, azithromycin tends to be more effective in terms of lower incidence of treatment failure and adverse events than amoxycillin or amoxyclav. However, most studies were of unclear methodological quality and had small sample sizes; future trials of high methodological quality and adequate sizes are needed.

Azitromicina y prevención de la reagudización de la EPOC

Una reseña del grupo de infeccioso de la Sociedad Madrileña de MFyC