4 de agosto de 2015

(COCHRANE): En un paciente con asma bien controlado con LABA + Corticoides inhalados ¿se debe suspender el LABA?

(COCHRANE) En un paciente con asma bien controlado con LABA + Corticoide inhalado ¿se debe suspender el LABA?

Stopping long-acting beta2-agonists (LABA) for adults with asthma well controlled by LABA and inhaled corticosteroids


Authors' conclusions

This review suggests that stopping LABA in adults who have stable asthma while they are taking a combination of LABA and ICS inhalers may increase the likelihood of asthma exacerbations that require treatment with oral corticosteroids, but this is not certain. Stopping LABA may slightly reduce asthma control and quality of life, but evidence was insufficient to show whether this had an effect on important outcomes such as serious adverse events and exacerbations requiring hospital admission, and longer trials are warranted. Trialists should include patient-important outcomes such as asthma control and quality of life and should use validated measurement tools. Definitions of exacerbations should be provided.

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